Laboratory for Behavioral Neurophysiology of Memory

Publications

Publications

Learning-dependent changes in the neuronal correlates of response inhibition in the prefrontal cortex and hippocampus.
Year of publication 2014
Title of paper Learning-dependent changes in the neuronal correlates of response inhibition in the prefrontal cortex and hippocampus.
Author Lee, I. and Byeon, J.S.
Publication in journal Experimental Neurobiology
Status of publication published
Vol 23
File 첨부 lee_byeon_en_2014.pdf (1.0M) 12회 다운로드 DATE : 2017-06-06 16:51:47

It has been suggested that the hippocampus and the prefrontal cortex (PFC) play key roles in representing contextual memory and utilizing contextual information for flexible response selection. During response selection, a correct response should be facilitated and an incorrect response should be inhibited flexibly in association with a cueing stimulus. However, it is poorly understood how the hippocampal and PFC networks behave during such flexible control of facilitation and inhibition of behavioral responses. To find neural correlates of context-cued flexible response selection, the current study employed an object-place paired-associate (OPPA) task in which object A is only rewarded in place 1 and object B is associated with reward in place 2 while recording single units simultaneously from the hippocampus and PFC. During the task, response inhibition in front of a contextually wrong object is required for successful performance and such inhibitory responses were observed before the rat learned the task. A significant proportion of neurons that fired differentially depending on the existence of inhibitory behavior in the PFC was observed during the pre-learning stage. By contrast, the proportion of such neurons in the hippocampus was significantly greater than chance during post-learning stage. The results suggest that the development of inhibitory behavior is a critical behavioral marker that foretells an upcoming acquisition of the task and the hippocampus and PFC are involved in learning contextual response selection by learning how to control the inhibition of behavior as learning progresses.